Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ھڪڙو نادر چمڙي جو ردعمل آھي جيڪو 90٪ ڪيسن ۾ دوائن جي استعمال سان لاڳاپيل آھي. Acute generalized exanthematous pustulosis اوچتو چمڙي جي ڦاٽڻ جي خاصيت رکي ٿو، جيڪا دوا شروع ٿيڻ کان پوء سراسري طور پنجن ڏينهن اندر ظاهر ٿئي ٿي. اهي ڦاٽا ننڍڙا، ڳاڙها اڇا يا ڳاڙها ڦاٽا آھن جن ۾ بادل يا purulent مواد (pus) موجود ھوندو آھي. چمڙي جا زخم عام طور تي 1‑3 ڏينهن اندر حل ٿي ويندا آھن، بشرطيڪه نقصانڪار دوا بند ڪئي وڃي.
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erythema ۽ pustules سان گڏ وسيع زخم اوچتو ظاهر ٿيندا آهن.
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ReferencesAcute generalized exanthematous pustulosis (AGEP) هڪ چمڙي جو ردعمل آهي جيڪو ڳاڙهي چمڙي تي ننڍڙن، پسن سان ڀريل bumps جي صورت ۾ ظاهر ٿئي ٿو. اهو عام طور تي ان وقت ٿيندو آهي جڏهن ڪو شخص اينٽي بايوٽڪ جهڙيون دوائون وٺي ٿو ۽ جلد سڄي جسم ۾ پکڙجي ويندو آهي. ٽريگرنگ دوائن کي روڪڻ کان پوءِ، علامتون عام طور تي ٻن هفتن اندر ختم ٿي وينديون آهن، اڪثر ڪري چمڙي جي ڇنڊڇاڻ سان. جيتوڻيڪ اڪثر صورتن ۾ صرف چمڙي تائين محدود هوندي آهي، سخت ڪيسن کي Stevens-Johnson syndrome يا toxic epidermal necrolysis جھڙن سنگين چمڙي جي ردعملن سان گڏ درجه بندي ڪري سگهجي ٿو. علاج بنيادي طور تي مددگار آهي، ۽ بيماري جي مڪمل بحاليءَ جي پيشنگوئي عام طور تي بهترين آهي.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
هڪ 76 سالن جو ماڻهو ايمرجنسي روم ۾ آيو ڇاڪاڻ ته هن جي چمڙي گذريل ٻن ڏينهن کان تبديل ٿي چڪي هئي. ڊاڪٽرن هن جي ٽنگ ۽ هٿن ۽ پيرن تي ڳاڙهي پيچ ۽ بلند ٿيل علائقا ڏٺا. جيئن جيئن وقت گذرندو ويو، تيئن تيئن اهي پيچ پاڻ ۾ شامل ٿي ويا، ۽ هن ڳاڙهي علائقن ۾ داڻا جھڙا ڦڙا پيدا ڪيا. ٽيسٽ ڏيکاريا آهن اعلي اڇي رت جي سيلن جي ڳڻپ ڪيترن ئي قسمن سان جنهن کي نيوٽروفيلس سڏيو ويندو آهي، ۽ C-reactive protein جي وڌندڙ سطح.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
